{"id":1087648,"date":"2024-06-04T09:01:33","date_gmt":"2024-06-04T08:01:33","guid":{"rendered":"https:\/\/biocoach.health\/2024\/06\/04\/rapamycin-effects-on-aging-and-longevity\/"},"modified":"2024-06-04T09:36:42","modified_gmt":"2024-06-04T08:36:42","slug":"rapamycin-effects-on-aging-and-longevity","status":"publish","type":"post","link":"https:\/\/biocoach.health\/en\/2024\/06\/04\/rapamycin-effects-on-aging-and-longevity\/","title":{"rendered":"Rapamycin – effects on aging and longevity"},"content":{"rendered":"\n

Rapamycin<\/a> is a special molecule that helps our cells do their job better and slows down the ageing process. It works by switching off a protein called mTOR, which is like a boss that tells our cells how to grow, eat and repair themselves. There are two versions of mTOR: mTORC1 and mTORC2 – and rapamycin mainly acts on the first version.<\/strong><\/p>\n\n

When mTORC1 is switched off, there are some positive effects<\/a> on our body:<\/p>\n\n

    \n
  1. Extension of lifespan: Studies on worms, fruit flies and mice<\/a> have shown that taking rapamycin can increase their life expectancy.<\/li>\n\n\n\n
  2. Slowing down the ageing process: Rapamycin helps<\/a> to reduce damage to our cells, improve their function and correct problems with cell division.<\/li>\n\n\n\n
  3. Relieve age-related diseases: It can help with conditions such as diabetes, heart disease and brain diseases such as Alzheimer’s and Parkinson’s.<\/li>\n<\/ol>\n\n

    Scientists don’t know exactly how rapamycin causes these effects, but there are a few ideas: For example, rapamycin can help our cells clean up and recycle their waste, as well as change the way cells use energy, ultimately protecting our DNA.<\/p>\n\n

    Even though rapamycin seems to work like a miracle cure, there are some challenges to its use, for example:<\/p>\n\n

      \n
    1. Side effects: Rapamycin can cause some problems in animals, e.g. weakening of the immune system, stomach problems and blood sugar problems. We must therefore be cautious and test the active substance more intensively on humans to see whether these side effects also occur here.<\/li>\n\n\n\n
    2. Dosage: People are not sure how much Rapamycin to take or when best to take it to achieve optimal results. The dosage seems to vary significantly from person to person.<\/li>\n\n\n\n
    3. Administration: At present, rapamycin is usually taken as a pill or injected into the stomach. We may have to find better (more comfortable) ways of administering them.<\/li>\n<\/ol>\n\n

      Despite these challenges, scientists continue to study rapamycin and test it in clinical trials<\/a>. It could become a useful tool in the fight against ageing, age-related diseases and the promotion of longevity. However, we should be cautious and not use Rapamycin without hesitation, especially in comparison to other nutrients that are fundamental components of our longevity lifestyle.<\/p>\n\n

      If you want to learn more about Rapamycin, check out this podcast episode<\/a> of Peter Attia in conversation with Longevity experts Matt Kaeberlein and David Sabatini.<\/p>\n","protected":false},"excerpt":{"rendered":"

      Rapamycin is a special molecule that helps our cells do their job better and slows down the ageing process. It works by switching off a protein called mTOR, which is like a boss that tells our cells how to grow, eat and repair themselves. There are two versions of mTOR: mTORC1 and mTORC2 – and […]<\/p>\n","protected":false},"author":1,"featured_media":1087634,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[97,125,66],"tags":[216,101,215],"class_list":["post-1087648","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-micronutrients","category-nutrition","category-uncategorized","tag-molecule","tag-mtor-en","tag-rapanycin-en"],"yoast_head":"\nRapamycin - effects on aging and longevity - BIOCOACH Longevity<\/title>\n<meta name=\"description\" content=\"Rapamycin - effects on ageing and longevity: a useful tool in the fight against ageing and age-related diseases\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/biocoach.health\/en\/2024\/06\/04\/rapamycin-effects-on-aging-and-longevity\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rapamycin - 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Es wirkt, indem es ein Protein namens mTOR ausschaltet, das wie ein Chef ist, der unseren Zellen sagt, wie sie wachsen, essen und sich selbst reparieren sollen. 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What may surprise you, however, is what kind of watch these experts\u2026","rel":"","context":"In \"BioAge\"","block_context":{"text":"BioAge","link":"https:\/\/biocoach.health\/en\/tag\/bioage-en\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/01\/biocoach-smartwatch.jpg?fit=1000%2C667&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/01\/biocoach-smartwatch.jpg?fit=1000%2C667&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/01\/biocoach-smartwatch.jpg?fit=1000%2C667&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/01\/biocoach-smartwatch.jpg?fit=1000%2C667&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":1087276,"url":"https:\/\/biocoach.health\/en\/2024\/05\/24\/how-intermittent-fasting-works-autophagy-inflammasome-and-cell-aging\/","url_meta":{"origin":1087648,"position":3},"title":"How intermittent fasting works: Autophagy, inflammasome and cell aging","author":"KMR","date":"May 24, 2024","format":false,"excerpt":"A recent study investigated the effects of intermittent fasting on various biomarkers in young men who fasted during Ramadan. The aim of the study was to investigate the molecular changes during prolonged interval fasting and to evaluate their potential impact on health and longevity markers. The study involved 25 healthy\u2026","rel":"","context":"In "Nutrition"","block_context":{"text":"Nutrition","link":"https:\/\/biocoach.health\/en\/category\/nutrition\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/05\/IMG_0060.png?fit=1024%2C1024&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/05\/IMG_0060.png?fit=1024%2C1024&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/05\/IMG_0060.png?fit=1024%2C1024&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/05\/IMG_0060.png?fit=1024%2C1024&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":1087606,"url":"https:\/\/biocoach.health\/en\/2024\/06\/01\/astaxanthin-as-an-anti-ageing-factor\/","url_meta":{"origin":1087648,"position":4},"title":"Astaxanthin as an anti-ageing factor","author":"BIOCOACH","date":"June 1, 2024","format":false,"excerpt":"The carotenoid Astaxanthin, a member of the xanthophyll subclass, has numerous clinical benefits due to its unique effect on the cell membrane. It neutralizes free radicals and oxidants by absorbing or releasing electrons without becoming a pro-oxidant. Its linear structure and polar-nonpolar-polar arrangement allow it to fit precisely into cell\u2026","rel":"","context":"In "Micronutrients"","block_context":{"text":"Micronutrients","link":"https:\/\/biocoach.health\/en\/category\/micronutrients\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0144.png?fit=1024%2C1024&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0144.png?fit=1024%2C1024&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0144.png?fit=1024%2C1024&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0144.png?fit=1024%2C1024&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":1087624,"url":"https:\/\/biocoach.health\/en\/2024\/06\/03\/the-anti-ageing-spice-turmeric\/","url_meta":{"origin":1087648,"position":5},"title":"The anti-ageing spice turmeric","author":"KMR","date":"June 3, 2024","format":false,"excerpt":"Curcumin is a compound found in turmeric (also known as turmeric or saffron root), a spice commonly used in Indian and other Asian cuisines. It is a natural yellow dye that is safe to eat and can be used as a food coloring. Curcumin has attracted a lot of attention\u2026","rel":"","context":"In "Micronutrients"","block_context":{"text":"Micronutrients","link":"https:\/\/biocoach.health\/en\/category\/micronutrients\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0177.png?fit=1024%2C1024&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0177.png?fit=1024%2C1024&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0177.png?fit=1024%2C1024&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/biocoach.health\/wp-content\/uploads\/2024\/06\/IMG_0177.png?fit=1024%2C1024&ssl=1&resize=700%2C400 2x"},"classes":[]}],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/posts\/1087648","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/comments?post=1087648"}],"version-history":[{"count":1,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/posts\/1087648\/revisions"}],"predecessor-version":[{"id":1087649,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/posts\/1087648\/revisions\/1087649"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/media\/1087634"}],"wp:attachment":[{"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/media?parent=1087648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/categories?post=1087648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biocoach.health\/en\/wp-json\/wp\/v2\/tags?post=1087648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}